DIRECT ANSWER: start at Phase 4 (Resilience and Longevity). Optimize healthspan, redox, and longevity signaling.
Protocol foundation
The compound families mapped to this phase and the most burdened networks (RUO, practitioner-dosed). Links open BioRegen research write-ups for further reading.
MOTS-c
Mitochondrial-derived metabolic signaling. · Mitochondrial, Metabolic, Energy
5 to 10 mg M/W/F fasted
NAD+
Cellular energy and sirtuin substrate. · Mitochondrial, Longevity, Energy
100 to 300 mg s.c. 2 to 3x weekly
SS-31
Cardiolipin-targeted mitochondrial support. · Mitochondrial, Energy Read the research →
NNMT inhibition, NAD+ preservation. · Metabolic, Longevity Read the research →
5 to 10 mg daily
Retatrutideoverlay
Metabolic and weight regulation (GLP-1 class). · Metabolic Read the research →
0.25 to 0.5 mg weekly
Further research on the peptide profile you fit is published at BioRegen research. Research and education only, not a recommendation to purchase or self-administer.
Nutrient foundation
Magnesium Glycinate 400 to 600 mg evening · Omega-3 4 g daily · Methylated B Complex daily · Vitamin D3 5000 IU + K2 · Ubiquinol 200 mg · Zinc 30 mg
Lifestyle foundation
Sleep optimization · Walk after the largest meal · Resistance training 3x weekly · Hydration with electrolytes · Stress-resolution practices
Reasoning
EVIDENCE PRESENT: top drivers were . Phase selected as the earliest significantly burdened layer (contraction is addressed before expansion). UNKNOWN / NEEDS MORE DATA: labs, genetics, and history refine dosing and phase timing, which is set by nervous-system state, not a calendar.
The full arc
Phase 1 · Reduce Contraction
Lower allostatic load and restore nervous-system regulation.
Phase 2 · Restore Communication
Repair tissue and gut integrity, calm inflammation, restore cellular communication.
Phase 3 · Mitochondrial and Metabolic Expansion
Rebuild ATP production, metabolic flexibility, and mitochondrial signaling.
Phase 4 · Resilience and Longevitystart here
Optimize healthspan, redox, and longevity signaling.
Ask The Way In Coach
Questions about your profile, your phase, or where to focus. Education only; your practitioner builds the individualized plan.
Important. SignalOS is decision-support and education. It does not replace a licensed clinician. All protocols are reviewed and individualized by a practitioner. Peptides referenced are research-use-only and not approved to diagnose, treat, cure, or prevent any disease. For urgent or severe symptoms, contact a licensed medical professional or emergency services.